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7-Cl-O-Nec1
A necrostatin-1 analog with superior potency, selectivity and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM). Displays greater efficacy at inhibition of necroptosis in Jurkat cells with no non-specific cytotoxicity (100 nM). Ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Recommended for cellular and in vivo applications over necrostatin-15.
Categories: Coronavirus Research Tools, COVID-19/ Sars-Cov-2 Related Compounds
Specifications
Amino Acid Sequence
Description & Background
A necrostatin-1 analog with superior potency, selectivity and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM). Displays greater efficacy at inhibition of necroptosis in Jurkat cells with no non-specific cytotoxicity (100 nM). Ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Recommended for cellular and in vivo applications over necrostatin-15.