Scientific Blogs & News

Technical Insights from Peptide Research Chemists

Technical Guide

Choosing the Optimal Counter-Ion for Beta-Amyloid: TFA vs HCl vs NH4OH

Counter-ions play a pivotal role in the monomeric stability, aggregation propensity, and cellular cytotoxicity of synthetic and recombinant Beta-Amyloid peptides in biophysical research.

February 18, 2026

Read Article →

Protocols

Standardized Sonication Protocols for Alpha-Synuclein Preformed Fibrils (PFFs)

Detailed parameters for water-bath sonication to achieve consistent fibril fragment length distributions (20–50 nm) for in vitro seeding and primary neuronal culture uptake.

January 14, 2026

Read Article →

Biochemical Synthesis

Recombinant Uniform N15 and C13 Isotopic Labeling for High-Resolution NMR

How uniform >98% isotopic incorporation is verified through mass spectrometry and 2D HSQC NMR spectra for intrinsically disordered neurodegenerative proteins.

November 29, 2025

Read Article →