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C16
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM) 1. Inhibits ER stress-induced neuronal damage 2. Reduces brain PKR activation in vivo 3. Prevents apoptosis and IL-1 Beta production in an acute excitotoxic and neuroinflammatory rat model 4. Prevents Beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures 5. Cell permeable.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM) 1. Inhibits ER stress-induced neuronal damage 2. Reduces brain PKR activation in vivo 3. Prevents apoptosis and IL-1 Beta production in an acute excitotoxic and neuroinflammatory rat model 4. Prevents Beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures 5. Cell permeable.