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Fingolimod
An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3) 1. Potently inhibits regulatory T cell proliferation in vitro and in vivo 2. Enhances microvascular remodeling via expansion of arterioles and capillary networks 3. Potent immunomodulatory 4. Clinically effective agent for relapsing forms of multiple sclerosis 5.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3) 1. Potently inhibits regulatory T cell proliferation in vitro and in vivo 2. Enhances microvascular remodeling via expansion of arterioles and capillary networks 3. Potent immunomodulatory 4. Clinically effective agent for relapsing forms of multiple sclerosis 5.