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Imatinib Mesylate
Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM) 1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM) 2. It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors as well as several other cancers 3. Lowers Amyloid Beta levels by indirect inhibition of gamma-secretase without inhibiting gamma-secretase processing of Notch1 4.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM) 1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM) 2. It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors as well as several other cancers 3. Lowers Amyloid Beta levels by indirect inhibition of gamma-secretase without inhibiting gamma-secretase processing of Notch1 4.