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IOS-1
Antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis 1. Inhibits airway remodeling in mouse asthma model 2. Blocks MIF-induced autophagy 3. Inhibits experimental autoimmune diabetes in a mouse model, reducing islet antigen-specific proliferative responses and adhesive cell-cell interactions 4. Active in cellular and mouse models. Reverses Amyloid Beta-induced toxicity in mouse and human neuronal cell lines 5.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
Antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis 1. Inhibits airway remodeling in mouse asthma model 2. Blocks MIF-induced autophagy 3. Inhibits experimental autoimmune diabetes in a mouse model, reducing islet antigen-specific proliferative responses and adhesive cell-cell interactions 4. Active in cellular and mouse models. Reverses Amyloid Beta-induced toxicity in mouse and human neuronal cell lines 5.