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ISRIB
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM 1. Enhances spatial and fear-associated learning in mice and enhances cognitive function 1,2. Mechanism of action involves activation of eiF2β 3. Suppresses ER stress-induced inflammatory gene expression 4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production 5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models 6.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM 1. Enhances spatial and fear-associated learning in mice and enhances cognitive function 1,2. Mechanism of action involves activation of eiF2β 3. Suppresses ER stress-induced inflammatory gene expression 4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production 5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models 6.