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IU1
Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis 1,2. Inhibits Dengue virus replication 3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load 4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model 5. Cell permeable.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis 1,2. Inhibits Dengue virus replication 3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load 4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model 5. Cell permeable.