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LM11A-31 2HCI
A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells 1. Promotes functional recovery in a mouse model of spinal contusion injury 2. Protects neurogenesis after traumatic brain injury 3. Reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models 4. Stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV-associated neuropathogenesis 5. Orally active and blood-brain barrier permeant.
Categories: Neurodegenerative Related Compounds
Specifications
Amino Acid Sequence
Description & Background
A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells 1. Promotes functional recovery in a mouse model of spinal contusion injury 2. Protects neurogenesis after traumatic brain injury 3. Reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models 4. Stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV-associated neuropathogenesis 5. Orally active and blood-brain barrier permeant.