Home Products Neurodegenerative Related CompoundsLM22A-4

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N-3006-1

High-Purity Recombinant

Batch Tested • Purity Guaranteed • Fast US & Worldwide Dispatch

SKU: N-3006-1

LM22A-4

$228.00

Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB and activates TrkB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administration, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats ¹. Improves respiratory function in a mouse model of Rett syndrome ².

Size: 10.0 mg

1

In Stock – Ships within 24-48 business hours

Categories: Neurodegenerative Related Compounds

Specifications

Physical State: White lyophilized powder

Temperature Storage: -20°C

Temperature Shipping: Ambient

Source: Recombinant. Expressed in E. coli

Purity: >97% by Mass Spec.

Molecular Mass: Theoretical

Amino Acid Sequence

D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V

Description & Background

Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB and activates TrkB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administration, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats ¹. Improves respiratory function in a mouse model of Rett syndrome ².

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